Hospitals, schools and people fleeing violence have been “targeted by direct air strikes” that may amount to war crimes, the UN said.
Orouba Barakat, an opponent of the ruling Baath party, and her only child, journalist Halla Barakat, were found dead with stab wounds to their neck.
The Syrian war monitor that released the numbers said that government forces and their allies had killed more than 83,500 civilians since the war started.
Andrei Karlov was killed by an off-duty police officer who shouted “Don’t forget Aleppo” and “Allahu Akbar” as he opened fire.
At least 45 people had been killed in artillery bombardment of rebel-held eastern Aleppo on Wednesday.
Bashar al-Assad’s forces, supported by Iranian-backed militia and Russian air power, have since last week stepped up their offensive against rebel-held areas of Aleppo, bombing hospitals and damaging water supplies.
The conflict is marked by deep ethnic, doctrinal, sectarian and political divisions between national, regional and global powers. No political settlement in the near future could mean a de facto partition of the country.
When states dream, is Syria their nightmare?
At least 18 of 31 trucks in a UN and SARC convoy were hit; the convoy was delivering aid for 78,000 people in the hard-to-reach Urm al-Kubra town in Aleppo.
The Syrian Observatory for Human Rights said the attacks were carried out by either a Syrian or Russian aircraft, adding that there had been 35 strikes in and around Aleppo since the truce ended.
The truce between the army and rebels is the first since February, but opposition groups and a monitoring organisation say little has changed on the ground.
Prospects of a political deal appear dim due to the conflict between US and Russia on Assad’s future.
A decree published by the state news agency gave no reason for the replacement of Wael al-Halaki, whose government controls most of the war-torn country.
Syria’s opposition has warned the government may open the door just enough to defuse international pressure before restricting access again.
Basma Kodmani said opposition armed groups were backing the proposal, which would revive the “cessation of hostilities” that began at the end of February and applied to all groups except for Islamic State and the al Qaeda-linked Nusra Front.
Mohammed Alloush also said that without any of the opposition demands met, peace talks were a “waste of time”, adding that he did not expect peace talks to resume so long as the Syrian government remained intransigent and not ready to enter “serious negotiations”.
Mustafa Badreddine was one of the highest ranking officials in Hezbollah and assessed by the US government to be responsible for the group’s military operations in Syria, where it is fighting alongside the Syrian President Bashar al-Assad.
“We have a lot of salesmen in the European Council and only a few statesmen,” said Martin Schulz, the president of the European Parliament, bemoaning the current crop of EU government chiefs who are struggling to overcome a string of crises.
The surge in bloodshed in Aleppo wrecked the first major “cessation of hostilities” agreement of the war, sponsored by Washington and Moscow, which had held since February.
Washington and its allies have agreed to do more in their campaign to defeat ISIS, but more risks lay ahead.
Israel is seeking up to $10 billion more than the current 10-year package and billions more than the US administration is offering, partly by asking for guaranteed funding for missile defence projects hitherto funded on an ad hoc basis by the US Congress.
Although nearly 75 million children are considered in desperate need of education or help to stay in school, the UN children’s agency said only 2% of global humanitarian appeals are on average dedicated to education.
US Secretary of State John Kerry was in Geneva for meetings with other dignitaries to try to revive the two-month-old US and Russia-sponsored cessation of hostilities.
The al-Quds hospital was supported by international medical charity Medecins Sans Frontieres, which said it was destroyed after being hit by a direct air strike that killed at least three doctors.